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This accumulation is accompanied by downregulation of glutathione peroxidase 4 (GPX4), upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4), and elevated lipid peroxidationhallmarks of ferroptotic cell death (Taylor et al., 2008)

The pattern for chronic fatigue shows an elevated morning cortisol with levels dropping off rapidly during the day

Hernndez, Spanish National Research Council (CSIC), Spain

Either by a lack of available energy to the brain leading to reduced cellular function or by damage to brain tissue mainly due to overactivation of the immune system, creating inflammation